Caroline "Cathy" Ryan (née Muller) is the wife of Jack Ryan, Sr., Mother of Sally Ryan, Jack Ryan, Jr., Kathleen Ryan, and Kyle Ryan and daughter of Joe Muller. Cathy is also the aunt of Brian Caruso and his twin brother Dominic Caruso. Cathy was an ophthalmic surgeon at the Wilmer Eye Institute of Johns Hopkins University School of Medicine and a Professor of Surgery at Johns Hopkins. She later became the first lady when her husband became the President of the United States.


Five movies have been produced based on Tom Clancy novels featuring Jack Ryan, starring four different actors as Cathy Ryan: